The X-Files

When Gillian Anderson got pregnant at the start of the 2nd season, some network executives wanted her role recast. Executive Producer Chris Carter adamantly denied their request.

The character Senator Richard Matheson is named after Richard Matheson, whose writing inspired Kolchak (1974), the show that inspired Chris Carter to create The X-Files.

In the early years of the series, Mulder is a firm believer in extraterrestrials and Scully is skeptical. In real life this is the opposite, being Duchovny the skeptical and Anderson the believer.