Jean-Pierre has been working in a countryside area of France during the last thirty years. All inhabitants know that when they are ill the can count on him and Jean-Pierre is in love with his work. When he make ill, a new young woman goes to the area for working with him and learning how the things are in the zone. The new doctor will replace Jean-Pierre in early future. The cohabitation is not easy between two doctors. She is a young woman who goes to a countryside area for replacing a veteran man who does not want to be replaced at all.

'Irreplaceable' is directed by Thomas Lilti ('Les yeux bandés', 'Hipócrates'). The film is a french comedy written by Baya Kasmi ('La vie très privée de Monsieur Sim', 'Je suis à vous tout de suite'). François Cluzet ('Untouchable', 'One Wild Moment') and Marianne Denicourt ('La crème de la crème', 'Une folle envie') are the protagonist of 'Irreplaceable'.